Association between morphological manifestations of inflammatory bowel disease and biochemical markers of inflammation

Aim. To determine morphological and morphometric changes in the structure of mucous membrane large intestine their relationship with content short-chain volatile fatty acids fecal calprotectin patients inflammatory bowel disease. Materials methods. We examined 68 disease, including 30 women 38 men aged 20–66 years, 55 were ulcerative colitis 13 – Crohn’s Histological examination focused on intestine. Determination feces was performed using gas chromatography. Calprotectin measured samples by enzyme-linked immunosorbent assay. Results. Significant correlations found between epithelial disruption crypt architecture, infiltration density, histological activity. The higher degree inflammation severe course combined a lower level tissue nonspecific protection, which detected number goblet cells, eosinophilic neutrophilic leukocytes. There decrease concentration butyric acid disease compared controls, but more significant observed colitis. data have confirmed association acids, coprofiltrate, evidenced presence low (r = -0.412; levels severity 0.589; P 0.001), atrophy 0.458; ? < 0.05), density 0.434; 0.05). Conclusions. All are characterized specific picture, reflected different degrees inflammation. Morphometric parameters accurately show atrophic coprofiltrate.